A UK-based SME specialising in protein engineering in the drug discovery environment is offering its expertise in protein structure determination using X-ray crystallography. The SME is offering these services to smaller companies developing actives in the pharmaceutical, agrichemicals and consumer markets. It is envisaged that the partnerships with these companies will take the form of services agreements.
Small molecules are an important source of active agents in various industries, particularly the pharmaceutical industry, as well as the agrichemical and consumer products sectors. The effect of such molecules on the structure and therefore function of target proteins is critical. Therefore accurate modelling of target protein structure is of vital importance in the design and development of these active agents. This modelling can be difficult to achieve to the required level of accuracy and requires specialist skills and experience. A UK-based SME, whose staff has over 70 years of combined experience in the drug discovery sector, is offering its structure determination services to other SMEs, primarily in the pharmaceutical sector but also in the agrichemical and consumer products markets. The SME offers its expertise in the use of X-ray crystallography to accurately solve the structure of the protein target for a client's experimental molecule. The output of this process is the generation of a 3D model as well as an in-depth analysis of the structure as it relates to function as well as ideas and suggestions for drug design to help clients to progress their pipeline projects quickly and effectively. The SME is looking to partner with smaller companies, especially in the pharmaceutical sector but is also looking to work with companies operating in the agrichemicals and consumer products markets. The SME will provide its expertise in protein structure determination to assist the product development programmes of partner companies with the partnership envisaged as a services agreement.
Innovations and advantages
The SME has extensive experience in the drug discovery sector, with its employees having over 70 years of combined experience in this field. This will enable the SME to use its accumulated knowledge to quickly determine the appropriate methodology for use in a client's individual project ensuring that the data and resulting 3D structural model is as accurate as possible. This level of expertise also enables the SME to provide clients with an in-depth analysis of their molecule as well as suggestions for ways to optimise its activity and so aid the process of structure based drug design and potentially saving development time and cost.
06001015 Pharmaceutical Products / Drugs
06002001 Biochemistry / Biophysics
06002003 Enzyme Technology
06002004 Protein Engineering
Market application codes
04005 Biochemistry / Biophysics
04007 Enzymology/Protein Engineering/Fermentation
05007002 Pharmaceuticals/fine chemicals
Intellectual property rights
Type of partner sought
The SME is looking to form partnerships with other SMEs that are developing small molecule actives in the fields of pharmaceuticals, agrichemicals and consumer products. The SME will provide its structure determination services to help partners with their development pipeline programmes. These partnerships are envisaged to take the form of services agreements.