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EJP RD JTC2020: French company developing new targeting of enzyme therapies for lysosomal disease is seeking partners with complementary approaches

Profile ID: 92418

Profile type: Research Development Request

Status

4263

Annotation

A French start-up created in 2012 develops new therapeutic approach based on membrane receptor targeting and nanomaterials. The technology allows the targeting of drugs to lysosomes for therapies of lysosomal storage diseases or cancer. The company would like to establish new partnerships to develop lysosomal disease treatments combining enzyme replacement therapy with other therapeutics (gene therapy, chaperone,...) in order to make a joint proposal for EJP RD JTC2020 call for project.

Offer description

The company has developed new targeted therapeutics to treat Lysosomal Storage Disorders. Thanks to the company's proprietary synthetic derivatives, they provide a compound with high affinity for the mannose 6-phosphate receptor and resistant to phosphatases. These compounds can be easily grafted on the glucidic moiety of the proteins and allow the production of recombinant enzymes with a homogenous glycosylation for a best lysosomal targeting via the mannose-6-phosphate receptor. Up to date, the company obtained extended results on Pompe disease but they are looking for partners to apply their technology for the improvement of other therapeutic enzymes. The company is looking for partners willing to apply to the 2nd EJP RD Joint Transnational Call for Rare Diseases Research Project (JTC 2020) wich focuses on Pre-clinical Research to Develop Effective Therapies for Rare Diseases. Official deadline for the call : 2020/02/18 Deadline for the EoI : 2020/02/11 Anticipated duration of the project : 3 years

Technology keywords

06001013 Medical Technology / Biomedical Engineering
06001015 Pharmaceutical Products / Drugs
06002003 Enzyme Technology
06002004 Protein Engineering
06006006 Biological Nanomaterials

Market application codes

05003005 Drug delivery and other equipment

Profile date

01/27/2022 12:00:00 am

Cooperation

Type of partner sought

The company is looking for academic or private partners to develop combined innovative therapies for lysosomal diseases including orphan diseases. Different approaches like gene therapy and enzyme therapies can be complementary for better treatment. Partners developing gene therapies (or chaperone therapies) could associate enzyme therapy developed by the company.

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+7-495-231-19-01

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